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KMID : 0361020120550010030
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Korean Journal of Otolaryngology - Head and Neck Surgery
2012 Volume.55 No. 1 p.30 ~ p.36
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Porous Polyurethane Scaffold as a Tracheal Prosthesis Material
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Kim Han-Su
Chung Sung-Min
Jung Soo-Yeon
Kim Soo-Jin
Kim Kyung-Yeon
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Abstract
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Background and Objectives: The purpose of this study was to confirm the usefulness of the porous polyurethane scaffold as a tracheal prosthesis for repair of partial tracheal defect.
Materials and Method: A porous polyurethane (PU) scaffold was manufactured by salt-leaching method. Polyethylene glycol (PEG) was grafted onto the surface of the PU scaffold following surface ozonation treatment. Scanning electro-microscopy (SEM) was then performed to evaluate the morphklogy. For the biocompatibility evaluation, a 5×5 mm sized PU scaffold was implanted into the rabbit’s ear. A histological examination was performed with the tissue one month later. Polymerase chain reaction for tumor necrosis factor (TNF)-α, interleukin (IL)-6, procollagen, fibromodulin, fibronectin, and actin was also performed. The tensile strength was measured and compared with beagle’s trachea to evaluate the mechanical property of the prosthesis.
Results: The effect of ozonation and surface grafting with PEG was on the porous scaffold was confirmed by SEM and X-ray photoelectron spectroscopy. The histological examination showed a large amount of fibrous tissue and capillary had grown through the pores of the porous scaffold. The inflammatory reaction was not so severe. TNF-α and IL-6 were slightly elevated in the PU scaffold transplanted tissue. However, the concentration levels of the other cytokines were similar between transplanted tissue and normal tissue. The tensile strength was very similar with the beagle’s normal trachea.
Conclusion: The polyethylene grafted polyurethane scaffold is a good candidate prosthesis for tracheal reconstruction.
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KEYWORD
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Trachea, Polyurethane, Tissue scaffolds
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